n.甲糖寧(一種治糖尿病的藥)

Results: Significant improvement of dissolution of tolbutamide was found. 結(jié)果:甲苯磺丁脲片的溶出度有很大程度提高。

Methods: L-HPC was added into tolbutamide and its dissolution was measured. 方法:于甲苯磺丁脲中加入低取代羥丙基纖維素測定溶出度。

Tolbutamide, indomethacin and diclofenac interacted with each other, resulting in the decreased formation of metabolites catalyzed by CYP2C9. 底物藥物甲苯磺丁脲、雙氯芬酸和吲哚美辛之間存在代謝相互作用，導(dǎo)致生成相應(yīng)代謝物的產(chǎn)率降低。

OBJECTIVE To develop a method for separating and purifying the two main metabolites of tolbutamide, carboxytolbutamide (CTOL) and hydroxytolbutamide (OTOL), from human urine, then identify the production and determine its purity. 目的研究從生物體液(尿液)中分離純化甲苯磺丁脲的兩個(gè)主要代謝物羥基甲苯磺丁脲(OTOL)和羧基甲苯磺丁脲(CTOL)的方法,并對所得的產(chǎn)物進(jìn)行鑒定和含量測定。

intravenous tolbutamide tolerance test 靜脈甲磺丁脲耐量試驗(yàn)