病因

Induction of apoptosis by Etoposide was associated with up-regulation of mRNAs for the BH3 only proteins Noxa,and to a lesser extent,Bim. BH3-only蛋白Noxa的mRNA表達(dá)明顯上調(diào),Bim少量上調(diào)與依托泊苷誘導(dǎo)的細(xì)胞凋亡有關(guān)系;

Objective To study the expression level and significance of BH3-only protein Bim, Noxa, Puma in apoptosis of paclitaxel-induced gastric adenocarcinoma cells. 目的研究BH3only蛋白Bim、Noxa、Puma在紫杉醇誘導(dǎo)胃腺癌細(xì)胞凋亡中的表達(dá)水平及其意義。

Induction of apoptosis of gastric adenocarcinoma calls by Etoposide may be assocaited with up-regulation of the BH3 only proteins of the bcl-2 family,Noxa and Bim. 依托泊苷誘導(dǎo)的胃腺癌細(xì)胞凋亡與BH3-only蛋白Noxa和Bim表達(dá)上調(diào)有關(guān)聯(lián)。