超變量

E2 protein, including hypervariable region 1 (HVR1) in the N-terminal region, contains some epitopes that can induce neutralizing antibodies. 包括高變區(qū)的E2蛋白含有中和性抗原表位，能誘導(dǎo)機(jī)體產(chǎn)生中和性抗體。

Objective To clarify the significance of antibodies to hypervariable region 1(HVR 1) of hepatitis C virus (HCV) in chronic HCV-infected patients. 目的 探討慢性丙型肝炎病毒 (HCV)感染者血清中抗高變區(qū) 1 (HVR1 )抗體的多型性及其臨床意義。

Aim To study the sequence diversity of the hypervariable region 1(HVR1) in the putative envelope protein E2/NS1 of genotype III/2a HCV in Chinese patients. 目的研究中國丙型肝炎患者III/2a型丙型肝炎病毒(HCV)包膜蛋白E2/NS1高變區(qū)1(HVR1)序列變異的規(guī)律及意義。

The extremely high variability of HCV especially at the hypervariable region of its envelope protein draws back the research to develop a vaccine against it in the traditional ways. 由于HCV具有不同的基因型，基因突變率高，尤其是包膜蛋白中的高變區(qū)，使得傳統(tǒng)的疫苗制備方法在HCV面前顯得束手無策。

The invention discloses a hypervariable region 1 antigen in hepatitis C virus (HCV), and also discloses the purpose of the antigen in the preparation of hepatitis C virus detection reagent. 本發(fā)明公開了本發(fā)明提供丙型肝炎病毒(HCV)第一高變區(qū)抗原，還公開了該抗原在制備丙型肝炎病毒檢測試劑中的用途。