半胱天冬酶

Caspase family is highly similar to the protein CED of Caenorhabditis elegans on gene sequence and protein structure. Caspase是與秀麗隱桿線蟲死亡蛋白CED在基因序列和蛋白質(zhì)結(jié)構(gòu)上高度同源的一個蛋白家族，該家族蛋白是細胞凋亡執(zhí)行的重要分子，直接參與凋亡啟動、凋亡信號傳遞及凋亡效應(yīng)過程。

Objective To investigate the expression of Caspase 3 in the hippocampus of acutely pentylenetetrazole-kindled rats. 目的 研究 Caspase- 3在戊四氮 (pentylenetetrazole,PTZ)急性點燃大鼠海馬組織中的表達情況。

The serum alanine transferase (ALT), hepatic Fas mRNA, caspase 3 activity and hepatocyte apoptosis were analyzed. 測定各組的血清谷丙轉(zhuǎn)氨酶 (ALT)、肝組織Fas mRNA表達、caspase 3活性和肝細胞凋亡。

Furthore, Bax translocation, cytochrome c release, and caspase 9 activation wereblocked by Z-VAD. Bax的膜轉(zhuǎn)移、細胞色素C的釋放以及Caspase 8

It is a protective mechanism of NGF by inhibiting the caspase cascade reaction induced by caspase-12. 抑制caspase-12介導的caspase級聯(lián)反應(yīng)性凋亡途徑的激活是NGF減少缺血/再灌注損傷細胞凋亡的機制之一。