n.[化]親核試劑

Amines can engage in nucleophile substitution reaction with alky. 胺能參加與鹵代烷的親核取代反應。

For a nucleophile, its regioselectivity is also controlled by both steric hindrance and electronic effect. 對于親核試劑，一般的親核試劑也同時受電子效應和空間效應的影響；

The target tripeptide was synthesized in ethanol/ This-HCl buffer system with Bz-Arg-OEt as acyl donor and Gly-Asp-(NH2)2 as the nucleophile. 然后以Bz-Arg-OEt為酰基供體，以Gly-Asp-(NH2)2為親核試劑，在乙醇/Tris-HCI反應體系中，用胰蛋白酶作催化劑催化合成了目標三肽。在試驗中我們發(fā)現(xiàn)經(jīng)過pH處理過的胰蛋白酶與酶粉作為催化劑相比具有的催化活力更高，產(chǎn)物產(chǎn)率好的優(yōu)點。

The kinetic data indicated that the mono-deprotonated oxime group could act as an effective intramolecular nucleophile in the reaction. 實驗結(jié)果表明，單去質(zhì)子化的肟基可以作為反應過程中的分子內(nèi)親核劑。

Catalyzed by sulfuric acid, 2 and 5 were converted to the same product (such as 3c) 3 (or 4) when mercaptan (or phenyl-sulfohydrate) was used as the nucleophile. 所得加成產(chǎn)物在酸催化條件下以乙硫醇為親核體時生成芳基乙基硫醚;